HAZARDS IDENTIFICATION EMERGENCY TELEPHONE NUMBERS (302) 451-0100 (FMC Plant - Newark, Delaware) (303) 595-9048 (Medical - U.S. - Call Collect) For leak, fire, spill, or accident emergencies, call: (800) 424-9300 (CHEMTREC - U.S.A. & Canada) (703) 527-3887 (CHEMTREC - Collect - All Other Countries) EMERGENCY OVERVIEW: Off-white, free-flowing, odorless powder. It flows and compresses extremely well, properties that endear this material wide scope of use in many fields. Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. CAS 9004-34-6, pH 5 - 7.5. Material Safety Data Sheet or SDS for Microcrystalline cellulose 9004-34-6 from chemicalbook for download or viewing in the browser. Remove Trademarks: Avicel PH-102. Doses up to 30 g per day appear to be . : 9 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication . /Contents 4 0 R Microcrystalline Cellulose (MCC) MSDS 1. stream %PDF-1.4 The wood pulp is depolymerized by acid hydrolysis and turned from a fibrous material to a white freely-flowing powder. Material Safety Data Sheet TALSTAR S INSECTICIDE Version 1 Page 1 / 8 SDS # : 6320-A This MSDS has been prepared to meet U.S. OSHA Hazard Communication Standard 29 CFR 1910.1200 and Canada's Workplace Hazardous Materials Information System (WHMIS) requirements. : 5. Note that Avicel Microcrystalline cellulose is available in different particle sizes and moisture grades that have different properties and applications. B;vLZpHU%ChUyD+[ endobj . Formulators select it when they need to enhance a formulations robustness especially when less compactable diluents and binders are used. Performing this action will revert the following features to their default settings: Hooray! X\o^ <> Avicel Microcrystalline cellulose also serves as a moisture adsorbent and as a general-purpose formulation improver. cas:9000-11-7 msds Carboxymethyl cellulose. The current product range and recommended usage are summarised below: Microcrystalline Cellulose is currently listed in the United States Pharmacopoeia and National Formulary, the European Pharmacopeia, the Japanese Pharmacopoeia, the British Pharmacopoeia, in addition to the Indian and Chinese Pharmacopeia, to name but a few. ). endobj To overcome the pitfalls of known overlays, we tested suspensions of microcrystalline cellulose Avicel RC/CLtrade mark as overlay media in the plaque and plaque-inhibition assay of influenza viruses. lH5JWy}DgKRR"Fs Heavy metals, % NMT 0.001 The short-term limit for total inhalable dust is 20 mg/m3. However, consumption of large quantities of the material may have a laxative effect. Various Gelcarin and Viscarin carrageenan grades are used by the pharmaceutical industry to achieve specific gelling for controlled drug release, thickening, and stabilizing properties desired in various formulations. <> PDF (28.38 mb) 2022 Corporate Fact Sheet. Avicel Microcrystalline Cellulose Physical Properties. Production of Pharmaceutical Grade Microcrystalline Cellulose. Enter your [postal] code to see information about local products, representatives and retailers, along with special offers in your area. Avicel co-processed grades are co-spray dried blends of Avicel microcrystalline cellulose with synergistic pharmaceutical excipients to yield functional benefits beyond simple physical blends. Alginates also function as actives in some anti-reflux products. <> . Avicel Microcrystalline cellulose is available in many grades, which differ in particle size, bulk density, and moisture content. 8 0 obj : 5 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication Standard, 29 CFR 1910.1200 and Canadas Workplace Hazardous Materials Information System (WHMIS) requirements. Avicel RC-591 offers ideal thixotropic bahavior for stabilizing suspensions while Avicel CL-611 is a stabilizer for reconstitutable or dry suspension formulations. FIRST AID MEASURES Eye Contact Hold eyes open and rinse slowly and gently with water for 15 to 20 minutes. Catalog Number 102331. Low use levels of GRINDSTED Xanthan Gum are sufficient to provide desired viscosities and textures. The data shown below apply only to Avicel PH 101. There have always been two different points of view for the liquidity of MCC. vdZ@Rgl{eU+7N!3!|hUmW)~}U*7k i@j)q["MEydtP"ftFu]t }JN~A"8lz7#}J.i@ qaj/QU<5OrVMfl{pL? common form is used in vitamin supplements or tablets. Revision No. MATERIAL SAFETY DATA SHEET Avicel RC/CL Microcrystalline Cellulose and Sodium Carboxymethylcellulose MSDS Ref. Microcrystalline cellulose was negative in the Ames mutagenicity assay [FMC Study Number I91-1189], and caused no EMCOCEL XLM 90. SEM micrographs of microcrystalline cellulose (MCC) models with a scale bar of 100 m [1] . LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such . }[eD-1-8$#Yi^$o8Nc6vwfw;wBT~[Rgi1?%T*/J:/'+Gf'Ae*j@{Rh+2oN|Sbtt;z#v8})F#z=:*]q+U>+ .e ^Q-{@ RPC t/(If>8P&%wNPMJw,VI2aUqRqe3bC,a;C&4RQSf*(=I$r{'%jmk1LUZV(*is6r&wQPAAoID4p?,"lp:wE+)v(_w 'yelVnMh=gIYjK:9v{$G;b8=lGG1_,h^0F2`a~Kusz1p#NS*qt6,F:7+Rma-4u} DINFzJ"Mlctg*~HEge With an account you can check out faster, view your online order history and access your shopping bag or saved items from any device. The Microcrystalline Cellulose monograph will be incorporated into and become official with the Second Supplement to . Carboxymethyl Cellulose Sodium N/A Nutrition & Biosciences www.pharma.dupont.com HO 00017 - 0 E L 02.2020 www.dupontnutritionandbiosciences.com . Avicel is one of the best-known pharmaceutical excipient brands and, without doubt, one of the most frequently used raw materials in solid oral product formulation and manufacture. << Microcrystalline cellulose is produced by subjecting to a high shear treatment, at elevated temperature and pressure, a reaction mixture of a cellulose material, an active oxygen compound and water, for a time effective to depolymerize the cellulose material. Have an order or account question, find answers in our Online Support articles. The global microcrystalline cellulose (MCC) market was valued at $401.1 million in 2021, and is projected to reach $712.9 million by 2031, growing at a CAGR of 5.9% from 2022 to 2031. 0.25 - 0.37. The product range encompasses methylcellulose and hydroxypropyl methylcellulose (hypromellose) each available in different grades to address a wide range of applications including tablet coatings, granulation, controlled release, drug layering, vegetarian hard-shell capsules and amorphous drug stabilization. Its used in capsules and tablets, both in wet granulation and direct compression processes, where it serves as a moisture adsorbent, tablet, and capsule diluent, and tablet disintegrant.It is also widely used as a supplementary formulation aid, primarily to enhance the . PDF (2.77 mb) 2021 FMC Sustainability Report. This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication Molecular weight: Not Applicable 1.5. %PDF-1.4 No. HMo@9, U Q!R/1*;` << GRINDSTED Xanthan Gum readily dissolves in water under ambient conditions without the need of special high-shear equipment. It is hygroscopic and insoluble in water. stream Find answers in our support articles. Gloves, eye protection and a dust mask should be used. Foam Booster/Stabilizer; Rheology Modifier; Stabilizer-Emulsion; Suspending Agent . The 'Substance identity' section is calculated from substance identification information from all ECHA databases. Microcrystalline cellulose is a term for refined wood pulp and is used as a texturizer, an anti-caking agent, a fat substitute, an emulsifier, an extender, and a bulking agent in food production. Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Page 1 of 9. Carrageenan is a naturally occurring family of hydrophilic polysaccharides extracted from several closely related species of red seaweeds. IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING 1.1 Product identifiers Product name : Avicel PH-101 Product Number : 11365 Brand : Fluka CAS-No. We know that our customers need to provide reliable and consistent products to their patients. *r_ *?~4$ &0Y# Microcrystalline cellulose (C6H10O5)n is refined wood pulp. Learn about FMC's differentiated biologically-based crop solutions. In summary, Avicel microcrystalline cellulose is virtually inert, its energy content is very low or zero and it is not absorbed. >z+{!A6wy @nLK3R#hRn sba3;b61V:#Z3X,*?RC!wPmqd7WkA'aZMt6PFV3SEvlY'=p.mn[I{puc\6'ZIyI%rD'zA!"t3I2F ^R;LK,?:&THv*y^K> o0Af?J9J-{s2&cCn)32ADzl%sS5O~J[ 0.25 - 0.37. It is generally regarded as a relatively nontoxic and non-irritant material that is safe for human and animal consumption. Cellulose microcrystalline. Regulatory Information 10.1 Future Forecast of the Global Microcrystalline Cellulose Market from 2023-2028 Segment by Region 10.2 Global Microcrystalline Cellulose Production and Growth Rate Forecast by Type (2023-2028 . From anti-reflux to biomedical implants, alginates are uniquely suited for a wide range of applications. However, it yields non-digestible fibre. Similarly, the European Food Safety Agency has also evaluated Microcrystalline cellulose and established that it is not absorbed systemically and excreted unchanged. Some substance identifiers may have been claimed confidential, or may . It is . %&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz )rFHVNzNaJlIo$5ZH(`8Z>s'$UVVWUyD+[t? Ui[(lY[|//o)ZmqbQT-Y.M|se[)m?(WRV.W8J/j}9>X.VNsZNOp'^14nuXM%rea5]@ MKnNe AFFINISOL hydroxypropyl methylcellulose (HPMC) is a water-soluble cellulosic polymer that can help optimize solubility enhancement of poorly soluble drugs by maintaining stable solid dispersions and inhibiting API crystallization. The most. We are artists at heart and creators by nature. X]s ;/4'OslUK:|QY`IL|w @ I!*2T~IN?*}y2*49]yOQ*VG%Gu,;&9zE{q==xvrv}rd(yG*qN6E0K$IBWhe 1 0 obj Since cellulose contains both amorphous and crystalline regions, when the crystalline regions are mechanically and chemically isolated and elaborated, various useful ingredients in the form of cellulose crystals are obtained, one of which is Avicel Microcrystalline cellulose. We can send by Fedex, by ship or by plane according to international rules. Studies from the World Health Organisation and the European Food Safety Agency have concluded that Microcrystalline cellulose has no safety concerns for the public when used in animal nutrition. This is unlikely to be a problem when Microcrystalline cellulose is consumed as part of a medical product where it is used as an excipient in the formulation. FMC Corporation 2929 Walnut Street Philadelphia, PA 19104 (215) 299-6000 (General Information) . Document(s): certificate data msds. F. Steele, M. Tobyn, S. Edge, A. Chen & J. N. Staniforth.Physicochemical and Mechanical Evaluation of a Novel High Density Grade of Silicified Microcrystalline Cellulose, Drug Development and Industrial Pharmacy, 30:1 (2004), 103-109. However, with many different grades (standard and specialty) on offer, how do you select the correct material for your needs? Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Manufacturer FMC Corporation Product code 103-B Revision date 2014 September 30 Language English. Manufacturer: FMC BioPolymer. Instead, they obtained a stable colloidal suspension. (&E. Within the pharmaceuticals field, where the bulk of this material is utilised, Avicel Microcrystalline cellulose functions as a filler and diluent, dry binder, flow, disintegrating, and compression aid in tablets, capsules, and granules. 1.3. Van Veen, G.K. Bolhuis, Y.S. 3t;zAXa[j.7ZX[GL9e,>6sVV`T6`#W Microcrystalline cellulose (MCC) for industrial purposes is usually obtained from wood pulp and purified cotton linters. 1.3. Chemsrc provides Cellulose microcrystalline(CAS#:9004-34-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Currently, it is marketed both directly and indirectly (through distributors) depending on the country in question. Test Data Available. 2021 Annual Report. Avicel PC 611 Microcrystalline Cellulose. 2008-2023 ChemPoint. The charts below provide guidance on how to select and use standard and co-processed grades of Avicel Microcrystalline cellulose in pharmaceutical products. Their nomenclature and recommended applications are shown below: Co-processed Avicel grades are high functionality materials designed to bring added performance over and above what standard grades offer. Synonyms: Cellulose, Cellulose powder, Cotton linters. 4 0 obj FMC, JRS and Mingtai were estimated to hold for . stream %PDF-1.3 q9;v80q>jZ Place an order online, track your orders, download SDS and TDS, and see your quotes, all in one secure place. Microcrystalline Cellulose E460 MSDS 1. Fmc Corporation: Ultra-fine microcrystalline cellulose compositions and process . Microcrystalline cellulose (MCC) is a pure partially depolymerized cellulose synthesized from -cellulose precursor (type I), obtained as a pulp from fibrous plant material, with mineral acids using hydrochloric acid to reduce the degree of polymerization.
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