All individuals belonging to the Fournol cluster show higher affinity to Goyet Q116-1 than to the Sunghir group (n=4), and the Vstonice-cluster individuals show higher affinity to the Sunghir group than to Goyet Q116-1 (Extended Data Fig. 1 and 2). Data science is a lot like cooking. It was awesome seeing the thought process behind each of the questions - it helps students immensely! & Nielsen, R. ANGSD: analysis of next generation sequencing data. 21, 199 (2020). 26, 827833 (2016). Dismiss. The MDS analysis showing the genetic affinity among European hunter-gatherers was based on the distance matrix derived from outgroup f3-statistics, in the form 1f3(Mbuti.DG; pop1, pop2) and performed with classical MDS algorithm (cmdscale) implemented in R 3.5.1. She supports Propel on the business and marketing side. The long-lasting genetic continuity in Iberia is also reflected in the preservation until the Mesolithic of Y-chromosome haplogroup C, which was predominant in pre-LGM groups but rarely found after the LGM in other parts of Europe (Extended Data Figs. Curr. This is first detected in an individual from Gross Fredenwalde in northeastern Germany and reaches around 10% in most European hunter-gatherer individuals thereafter (Extended Data Fig. 4. 27, 18011810.e10 (2017). Nat. 2. Dual ancestries and ecologies of the Late Glacial Palaeolithic in Britain. Ecol. Data warehousing is a field that has to be done right. Billed once. October 28 Actress #31. However, published Gravettian-associated genomes originate from central and southern Europe, leaving the genetic profile of Gravettian-associated humangroups from western and southwestern Europe undescribed. We applied ANGSD 0.93470 and hapCon71 for libraries from male individuals, and applied contamLD72 and a newly developed method that analyses contamination in ROH for female and male libraries (see Supplementary Information, section2 for a detailed description). Internet Explorer). After 2 washing steps using the manufacturers wash buffer, DNA was eluted in TET (10mM Tris, 1mM EDTA and 0.05% Tween) in two steps for a final volume of 100l. Evol., https://doi.org/10.1038/s41559-023-01987-0 (2023). This was confirmed with qpAdm, in which we could model all individuals from the Oberkassel cluster as a broadly constant mixture of approximately 75% Arene Candide 16 and 25% Goyet Q-2 (or 90% Arene Candide 16 and 10% Fournol 85) (Fig. Commun. Article Google Scholar. (black) or 3s.e.m. Freshwater radiocarbon reservoir effects at the burial ground of Minino, Northwest Russia. 7, eabd6535 (2021). Here, we report genomic data from 4 individuals, including 3 approximately 13,000-year-old genomes from northeastern Italy (Pradis 1), northwestern Italy (Arene Candide 16) and Sicily (San Teodoro 2), as well as increased genome-wide coverage from Tagliente 215 dated to 17ka. One-time payment. Are you Tina Huang? Extended Data Fig. DNA analysis of an early modern human from Tianyuan Cave, China. I think its cool to see a project like this happen and I hope its interesting for people to learn more about how this stuff works. However, the level of genetic continuity between individuals associated with these cultures and the population structure among Epigravettian-associated individuals have not been fully explored. Curr. 3,528. My name is Tina and I'm a data scientist and YouTuber. Correspondence to Details of the modelling are provided in Supplementary Data 3.E,F. The incoming Villabruna ancestry later became the most widespread hunter-gatherer ancestry across Europe. The genomic similarity of the Oberkassel cluster to Arene Candide 16 in northwestern Italy might imply that Epigravettian-associated ancestry spread from the south to central Europe passing through the western side of the Alpine region. First, we show that individuals associated with the Gravettian culture across Europe were not a biologically homogeneous population. In this period, the Oberkassel-ancestry admixture spread further east, reaching Samara by around 6.5ka, and an increase in Sidelkino ancestry was detected in hunter-gatherers from the Baltic region, which was previously associated with the transition from the Narva culture to the Comb Ceramic culture38,39 (Extended Data Fig. www.sciencedaily.com/releases/2023/03/230301120846.htm (accessed March 4, 2023). ), no. Nat. 10, 1218 (2019). Adv. 15-star ratings) or unstructured data (such as social media reviews). We further validated the genetic distinction between the Vstonice and Fournol clusters observed in the MDS plot with a series of f4-statistics (Supplementary Data 2.B). 1c). Genetic ancestry changes in Stone to Bronze Age transition in the East European plain. OUR UNIVERSITY Our University . Natl Acad. Second, data-driven product development meshes very well with my own philosophy, commonly known as the 80/20 rule, where 80% of the results come from just about 20% of inputs. DNA was extracted from the generated bone or tooth powder following established protocols. BMC Bioinformatics 15, 356 (2014). This often involves analyzing similar products to compare how they performed. This is perfect for those of us who haven't a clue what to expect from data science - SQL portion - interviews. Upper Palaeolithic Siberian genome reveals dual ancestry of Native Americans. Bioinformatics 38, 37683777 (2022). 6, 16581668 (2022). However, the research team found no evidence for this, on the contrary: hunter-gatherer populations associated with the Gravettian culture and living in central and southern Europe are no longer genetically detectable after the LGM. Present-day individuals (gray dots) genotyped on theHumanOrigins dataset are used to define the PCA variation onto which ancient genomes (coloured symbols) are projected. PubMed Publication: Huang T, Reimand J. Network-rewiring mutation in kinase signaling networks are informative of cancer patient. Cosimo Posth, He Yu, Ayshin Ghalichi, Hlne Rougier, Isabelle Crevecoeur, Yilei Huang, Harald Ringbauer, Adam B. Rohrlach, Kathrin Ngele, Vanessa Villalba-Mouco, Rita Radzeviciute, Tiago Ferraz, Alexander Stoessel, Rezeda Tukhbatova, Dorothe G. Drucker, Martina Lari, Alessandra Modi, Stefania Vai, Tina Saupe, Christiana L. Scheib, Giulio Catalano, Luca Pagani, Sahra Talamo, Helen Fewlass, Laurent Klaric, Andr Morala, Mathieu Ru, Stphane Madelaine, Laurent Crpin, Jean-Baptiste Caverne, Emmy Bocaege, Stefano Ricci, Francesco Boschin, Priscilla Bayle, Bruno Maureille, Foni Le Brun-Ricalens, Jean-Guillaume Bordes, Gregorio Oxilia, Eugenio Bortolini, Olivier Bignon-Lau, Grgory Debout, Michel Orliac, Antoine Zazzo, Vitale Sparacello, Elisabetta Starnini, Luca Sineo, Johannes van der Plicht, Laure Pecqueur, Gildas Merceron, Graldine Garcia, Jean-Michel Leuvrey, Coralie Bay Garcia, Asier Gmez-Olivencia, Marta Potowicz-Bobak, Dariusz Bobak, Mona Le Luyer, Paul Storm, Claudia Hoffmann, Jacek Kabaciski, Tatiana Filimonova, Svetlana Shnaider, Natalia Berezina, Borja Gonzlez-Rabanal, Manuel R. Gonzlez Morales, Ana B. Marn-Arroyo, Beln Lpez, Carmen Alonso-Llamazares, Annamaria Ronchitelli, Caroline Polet, Ivan Jadin, Nicolas Cauwe, Joaquim Soler, Neus Coromina, Isaac Ruf, Richard Cottiaux, Geoffrey Clark, Lawrence G. Straus, Marie-Anne Julien, Silvia Renhart, Dorothea Talaa, Stefano Benazzi, Matteo Romandini, Luc Amkreutz, Herv Bocherens, Christoph Wiing, Sbastien Villotte, Javier Fernndez-Lpez de Pablo, Magdalena Gmez-Puche, Marco Aurelio Esquembre-Bebia, Pierre Bodu, Liesbeth Smits, Bndicte Souffi, Rimantas Jankauskas, Justina Kozakait, Christophe Cupillard, Hartmut Benthien, Kurt Wehrberger, Ralf W. Schmitz, Susanne C. Feine, Tim Schler, Corinne Thevenet, Dan Grigorescu, Friedrich Lth, Andreas Kotula, Henny Piezonka, Franz Schopper, Ji Svoboda, Sandra Szelov, Andrey Chizhevsky, Aleksandr Khokhlov, Nicholas J. Conard, Frdrique Valentin, Katerina Harvati, Patrick Semal, Bettina Jungklaus, Alexander Suvorov, Rick Schulting, Vyacheslav Moiseyev, Kristiina Mannermaa, Alexandra Buzhilova, Thomas Terberger, David Caramelli, Eveline Altena, Wolfgang Haak, Johannes Krause. This might have been in part triggered by the concomitant expansion of Neolithic farmers across Europe and/or by environmental factors, such as the climatic event around 8.2ka, the largest abrupt cooling in the northern hemisphere during the Holocene epoch46,47. For ds_halfUDG libraries, we masked 2bp from both ends of the reads with trimBam in bamUtil 1.0.13 (https://github.com/statgen/bamUtil) to remove the damaged sites. The mtDNA contamination was estimated by Schmutzi (--notusepredC --uselength)69 for all the libraries. Patterson, N. et al. Google Scholar. ADS Rohrlach, A. My name is Tina Huang and Im a data scientist at a FAANG company. But she came up with a way to break down the code and create a website that she was proud of. - Technical researcher and data analyst under the supervision of Dr. A. Meyer and Dr. S. Bae at UCLA. Citations 52. We can have either structured data (e.g. Content on this website is for information only. Ecol. What is surprising is that the Code Cup was so popular that Stanford decided to throw open a Data Science Week in which anyone can submit a code challenge to the top 200 submissions. Connect with them: Email: hellotinah@gmail.com. The levels of contamination from modern human DNA were estimated on the basis of mitochondrial DNA (mtDNA), X chromosome and autosomal DNA, and with a haplotype copying model that is extended here to autosomal data in runs of homozygosity (ROH) (Methods, Supplementary Information, sections2 and 3, Supplementary Figs. Interviewed Taiwanese designers and analyzed the interview data. Petr, M., Pbo, S., Kelso, J. assembled archaeological material, descriptions and interpretations. Olalde, I. et al. K.N., V.V.-M., R.R., T. Ferraz, R.T., D.G.D., M.L., A. Modi, S. Vai, T. Saupe, C.L.S., G. Catalano, L. Pagani, D.C. and E.A. 2011. Natl Acad. The tool qpAdm 810 in ADMIXTOOLS 5.1 was applied to model the ancestries of admixed populations, with allsnps mode and the outgroup set selection described in Supplementary Information, section11. The newly generated genotypes were merged with 240 published ancient hunter-gatherer genomes and modern worldwide populations for downstream analyses (Supplementary Data 1.G). I worked in bioinformatics in cancer research and then decided to a masters in computer science (MCIT) from the University of . CAS This article reviews qualitative and quantitative studies related to the academic achievement of youth from immigrant Chinese families. Tina is proud she taught herself SQL from scratch in 11 days to pass her FAANG SQL interview. 1999 - 20001 year. Tina Huang, a former engineer at Apple, Google, and Twitter, explains why she started API management startup Transposit. The pairwise f2 distance matrix of Epigravettian-associated groups was generated with qpfstats 200 in ADMIXTOOLS 7.0.2 package, with parameters allsnps: YES, scale: NO, and Mbuti.DG set as the outgroup. There is no biographical data to display. Dots are maximum likelihood estimates and error bars show 95% confidence intervals of the derived allele frequencies (n, the number of individuals in each group, is provided in Supplementary Data 3.G). This figure shows that the Gravettian-associated individuals from western Europe (Fournol cluster) are closely related to Goyet Q116-1 while the Gravettian-associated individuals from central-eastern and southern Europe (Vstonice cluster) are closely related to the Sunghir group, representative of the Kostenki cluster. 10 and 11). I hope you brings out more courses like these. Further information on research design is available in theNature Portfolio Reporting Summary linked to this article. 4. Proc. The dimensions are calculated using newly reported and previously published hunter-gatherer groups or individuals with more than 30,000 SNPs. Both double-stranded and single-stranded libraries were further amplified with IS5/IS6 primers to reach a concentration of 200400ng/l as measured on a NanoDrop spectrophotometer (Thermo Fisher Scientific). Meet Tina Huang. Nature 513, 409413 (2014). I also have a newsletter called Boop's Keyboard! Nature 534, 200205 (2016). Paleogenomic evidence for multi-generational mixing between Neolithic farmers and Mesolithic hunter-gatherers in the Lower Danube Basin. Science 338, 222226 (2012). The grouping of Epigravettian-associated populations is shown with the same colour in a. Max Planck Institute for Evolutionary Anthropology. Evol. 2022 Weird Science Plus - All Rights Reserved. The inferred pattern of short ROH (48 cM, visualized in blue) being common is in stark contrast to most later farmer populations, where the majority of individuals have no short ROH whatsoever (see101), and evidences small effective population sizes across West Eurasian hunter-gatherer groups. For the placement of individuals onto a Y-chromosomal phylogenetic tree (Extended Data Fig. Bioinformatics 20, 289290 (2004). Science 365, eaat7487 (2019). Our results show that the contact zone and the admixture patterns betweenthe Oberkassel and Sidelkino ancestries changed over time (Fig. (eds. Opin. Skoglund, P. et al. 27, 21852193.e6 (2017). Liet. Individuals with at least one library showing Y/Auto ratio > 0.2 were determined as maleindividuals, and with Y/Auto < 0.2 were determined as femaleindividuals4 (Supplementary Fig. We then removed samples with less than 0.04X coverage (calculated on the mappable, non-recombining region of the Y chromosome98) to avoid arbitrarily placing low-coverage samples at the root of major haplogroups. University Universit Chouaib Doukkali; . Nature 505, 8791 (2014). USA 110, 1575863 (2013). Tina Huang Fans Also Viewed . Biol. Using Y-chromosome capture enrichment to resolve haplogroup H2 shows new evidence for a two-path Neolithic expansion to Western Europe. Open access funding provided by Max Planck Society. Jobs People Learning Dismiss Dismiss. Notably, and contrary to the report by Fu et al.4, another Gravettian-associated population from centralwestern Europe (Goyet in Belgium, n=6 individuals) is both geographically and genetically intermediate between the Vstonice and Fournol clusters. Tina Huang is very empowering, and she knows what she is talking about. The pre-40kagroup and theFournol and Vstonice clusters are marked as shaded areas in different colours. Become the most confident candidate in the room. El Mirn has a significantly higher similarity to theVillabruna clusterthan Fournol 85 and Le Piage II, while the affinity to theVillabruna cluster in Le Piage II is not significantly higher than in Fournol 85 (Supplementary Data 2.D). It is generated automatically, and you can download, view, and share it at any time. Genome of Petera Muierii skull shows high diversity and low mutational load in pre-glacial Europe. Once we have the data, we begin to tease out the high-impact insights. is also supported by the Deutsche Forschungsgemeinschaft (DFG FOR 2237). Instead, in southern Europe, a distinct hunter-gatherer genetic profile was found as early as 17ka in individuals associated with the Epigravettian culture15 (2412ka, from the Italian peninsula to the southeastern European Plain across the Balkans). Sydney, Australia. This is also validated by f4-statistics of the form f4(Mbuti, Zlat k; test1, test2), which are consistent with zero for all other pre-LGM hunter-gatherers (Supplementary Data 2.C), indicating an equidistant relationship of Zlat k to the tested groups. of Leiden, 2000). Tina Huang is a recent graduate of Stanford. Conversely, the ancestry found in pre-30ka eastern European individuals (Kostenki cluster and Sunghir group) contributed to Gravettian-associated individuals from central and southern Europe (Vstonice cluster), the latter without descendantsretrieved in post-LGM populations from those regions. Extended Data Fig. All Rights Reserved. Korlevi, P. et al. 14, evac045 (2022). Cardiff, Wales, United Kingdom. Science 328, 710722 (2010). Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. PLoS ONE 14, e0217996 (2019). Ancient genomes from present-day France unveil 7,000 years of its demographic history. 38. 2022 Fab Business Solutions - All Rights Reserved. "Unlike diving into the university life directly, the pathways program is a buffer that allows international students to be better prepared. This finding, in conjunction with the genetic affinity of the Villabruna cluster to ancient and present-day Near Eastern ancestries4,15,16 (Supplementary Information, section8, Supplementary Fig. This project has received funding by the European Research Council under the European Unions Horizon 2020 research and innovation programme under grant agreements no. Article Tina Huang. The genetic prehistory of the Baltic Sea region. Green, R. E. et al. The admixture graph shows that the Bacho Kiro IUP group (n=3) shares ancestry with multiple early modern human lineages2 (Supplementary Information, section7), and that the more than 45,000-year-old Zlat k genome1 is the most deeply divergent non-African lineage sequenced to date (Extended Data Fig. For phylogenetic reconstruction (Extended Data Fig. The effective population sizes (Ne) were then estimated using a maximum likelihood method, after filtering individuals with a signal of close-kin inbreeding (individuals with at least 50 cM of their genome in ROH spanning >20 cM) (Supplementary Information, section9). This study focuses on the people who lived between 35,000 and 5,000 years ago and that are, at least partially, the ancestors of the present-day population of Western Eurasia, including -- for the first time -- the genomes of people who lived during the Last Glacial Maximum (LGM), the coldest phase of the last Ice Age, around 25,000 years ago. She is also a popular YouTuber with over 60k subscribers. TV Actresses. The competition is based on a pretty strict data set thats been collected by the Stanford Computer Science department. Tina Huang Profile page. Genome Biol. We further tested whether individuals included in the Vstonice and Fournol clusters share similar allele frequencies with the main representatives of those two clusters. Genetics and material culture support repeated expansions into Paleolithic Eurasia from a population hub out of Africa. Nature 582, 384388 (2020). Genome-wide patterns of selection in 230 ancient Eurasians. This, together with the evidence of Villabruna ancestry in El Mirn 19ka, further suggests that this genetic discontinuity could be the result of palaeogeographic and palaeoecological transformations connected to the LGM32, rather than to the BllingAllerd warming period4,15 (14.712.9ka). You need a lot of information to predict whats going to happen, but then you also need a lot of information to make decisions about what youre going to do. ather than doing some data analysis or looking at trends, we wanted to dedicate this bulletin to seven women in tech, data, and science that you should know about. Other individuals from that period, such as Zlat k from Czechia and UstIshim from Russia, do not carry significantly more Neanderthal ancestry than other non-African groups1,7, indicating differential interactions between Neanderthals and early modern humans during their initial expansions across Eurasia. Materials provided by Max Planck Institute for Evolutionary Anthropology. Besides El Mirn, who has around 43% Villabruna ancestry, all other Magdalenian-associated individuals have a lower proportion of this component (1929%) and can thus be assigned to the GoyetQ2 cluster (Fig. Subsequently, I worked in bioinformatics for a year and then did my Masters in computer science (MCIT) at the University of Pennsylvania. Sci. 31, 24842493.e7 (2021). Libraries were quantified using the IS7 and IS8 primers59 in a quantification assay using a DyNAmo SYBR Green qPCR Kit (Thermo Fisher Scientific) on the LightCycler 480 (Roche). Extended Data Fig. Lead Advisor - Data Science. (grey) of the f4 values estimated from 5cM-block jackknife analysis. Ancient genomes indicate population replacement in Early Neolithic Britain. Notably, this genetic distinction coincides with dissimilarities in mortuary practice among genetically analysed Gravettian-associated individuals from different parts of Europe. Error bars show 1s.e.m. In no time, she established herself as one of the favorite vloggers of the data community. 4, 324333 (2020). ADS Kristen Bell. This raises the possibility that the replacement by the Oberkassel cluster and the formation of the Sidelkino cluster might have been the result of population expansions influenced by the abrupt warming during the BllingAllerd interstadial4,24. the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Details are provided in Data S2.B. Subsequently, I worked in . F-statistics suggest that Le Piage II is genetically intermediate between Fournol 85 and El Mirn (Supplementary Data 2.D). Substantially contaminated libraries as well as marginally contaminated libraries of individually analysed genomes were filtered to maintain reads showing postmortem DNA damage (Methods and Supplementary Figs. . Nat. "At that time, hunter-gatherers with distinct ancestries and appearances started to mix with each other. On top of that, its full of useful career and productivity advice, so you can find out what knowledge you need to become a data scientist as well as how to break into the field. In addition to this general data science content, Tina teaches SQL . The nuclear DNA contamination was estimated with several methods. Genomic diversity and admixture differs for stone-age Scandinavian foragers and farmers. I have an undergraduate degree in . Corporate Financial Managementspring term (BS 2508) Second year of undergraduate. Ancient genome-wide DNA from France highlights the complexity of interactions between Mesolithic hunter-gatherers and Neolithic farmers. Raghavan, M. et al. She then served as a postdoctoral associate at the National Institute of Standards and Technology. 6 West Eurasian PCA showing the genetic positioning of post-LGM hunter-gatherers. Now we have Areej AbuAli, an SEO manager and the founder of Women in Tech SEO. . 8). analyzing similar products to compare how they performed, data visualizations with SQL and Python or R, Unimex NetworkPrice Analysis 2021 UMX Token Price Forecast 2021 Umx Token Price Prediction 2021, NKN Token Price Analysis 2021 Nkn Token Price Forecast 2021 nkn Token Price Prediction 2021, CRED Price Analysis 2021 LBA Token Price Forecast 2021 Lba Token Price Prediction 2021, Pearl Price Analysis 2021 PEARL Token Price Forecast 2021 pearl Token Price Prediction 2021, JackPool Price Analysis 2021 JFI Token Price Forecast 2021 Jfi Token Price Prediction 2021, CyberFi Price Analysis 2021 CFI Token Price Forecast 2021 CFI Price Prediction 2021, UNISTAKE Price Analysis 2021 UniStake Token Price Forecast 2021 Unistake Price Prediction 2021, OctoFi Token Price Analysis 2021 OCTO Token Price Forecast 2021 Octo Token Price Prediction 2021, Hedera Hashgraph Price Analysis 2021 HBAR Token Price Forecast 2021 -Hbar Price Prediction 2021. ), Science . In her journey of eventually becoming a data scientist, Tina started out with an undergraduate in Pharmacology. Goutas, N. in Les Gravettiens (ed. The similarity between Goyet Q116-1 and Goyet Q376-3 and the Fournol cluster is also observed at the mtDNA level, with both groups including individuals who carried mtDNA haplogroup M, which has not been found in European individuals from after the LGM24 (Extended Data Figs. Well be back on Friday so, if youre not already, get subscribed to the Brandwatch Bulletin right away. Newsletter, Key, F. M. et al. You are using a browser version with limited support for CSS. Where it all started :) I make weekly videos about self learning, practical productivity, and coding. Posth, C. et al. J. Anthropol. It involves lots of hypothesis testing and statistics which 365 Data Science also has a wonderful course on. Antiquity 91, 573588 (2017). TV Actress. PACEA co-authors of this research benefited from the scientific framework of the University of Bordeauxs IdEx Investments for the Future programme/GPR Human Past. By co-analysing previously published data with our newly reported genomes associated with the Magdalenian from La Marche (18ka) and Pincevent (15ka) in western and northern France, respectively, and Maszycka (1816ka) in southern Poland, we confirm that the Goyet Q116-1 ancestry survived in all studied Magdalenian-associated genomes besides in Gravettian and Solutrean-associated individuals from southwestern and western Europe (Fig.
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