2008-2023 ChemPoint. Stir until uniform. Some products also contain sunscreens. Calorim. Eng. HMkA+"c>jZ^ho=81NW;]Ib;+i#iFArHpz). `9F6~qg3]0,#!V9Q> p=|h| Belhachemi, B., Makhlouf, H. & Belhachemi, M.H. Azelaic acid (AzA) is a organic compound with the formula HOOC(CH 2) 7 COOH. This is a preview of subscription content, access via your institution. The Beaver: Its Life and Impact. 115, 22772285 (2014), Article Unfortunately, retinoids, in particular retinoic acid, retinal, and their derivatives, isomers and analogs (such as adapalene, tazarotene and isotretoin) also have discoloration problems due to oxidation. "F$H:R!zFQd?r9\A&GrQhE]a4zBgE#H *B=0HIpp0MxJ$D1D, VKYdE"EI2EBGt4MzNr!YK ?%_&#(0J:EAiQ(()WT6U@P+!~mDe!hh/']B/?a0nhF!X8kc&5S6lIa2cKMA!E#dV(kel }}Cq9 Place an order online, track your orders, download SDS and TDS, and see your quotes, all in one secure place. Retinoids, in particular retinoic acid, retinal, and their derivatives, isomers and analogs (such as adapalene, tazarotene and isotretoin), are beneficial for improving rough skin texture, mottled pigmentation, sallow complexion, lines and wrinkles. F. Whler (1844) "Untersuchungen ber das Chinon" (Investigations of quinone). ORIGINAL CODE: 0009013, Ref document number: Solubility: Moderately soluble in water, glycerin, propylene glycol, and highly soluble in ethanol Features & Benefits Can work in conjunction with glycolic acid to help reduce pigment in melasma Non-GMO Extremely low vapor pressure USP Grade European Pharma Grade Drug master file available upon request Applications However, hydroquinone discolors at the pH range of 7.0 to 8.5. n3kGz=[==B0FX'+tG,}/Hh8mW2p[AiAN#8$X?AKHI{!7. [Na+].OC(=O)CC(O)(CC([O-])=O)C(O)=O.OC(=O)CC(O)(CC([O-])=O)C(O)=O, SPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS, Preparations for care of the skin for chemically bleaching or whitening the skin, PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES, Medicinal preparations containing organic active ingredients, Acids; Anhydrides, halides or salts thereof, e.g. Find answers in our support articles. Forms of retinoids have been developed wherein the retinoid is protected by a protective system. Compositions according to this invention may include additives or components to enhance the skin penetration of its ingredients. Res. and solubility in water. Antioxidants in the hydroquinone phase and inorganic or amino acyl cationic salts of acidic ascorbyl esters, preferably sodium metabisulfite and magnesium ascorbyl phosphate respectively, are effective in stabilizing such hydroquinone compositions, which are used in treatment of pigmentation disorders. Eastman Hydroquinone, USP, meets or exceeds the requirements of the United States Pharmacopoeia and is produced under conditions of current good manufacturing practices (cGMP). 0 7 r @ &. This complex dissolves in hot water, where the two molecules dissociate in solution. hydroquinone, 1,4-benzenediol, quinol, 1,4-dihydroxybenzene, p-benzenediol, 4-hydroxyphenol, p-hydroquinone, p-hydroxyphenol, p-dihydroxybenzene, benzoquinol, Electrophoresis, Western Blotting and ELISA, Chromatography and Mass Spectrometry Reagents, Laboratory Syringe Needles and Accessories, Lab Coats, Aprons, and Other Safety Apparel, Sharps Disposal Containers and Accessories, Classroom Laboratory Supplies and Consumables, Applied Biosystems TaqMan Assay and Arrays Search Tool, Applied Biosystems TaqMan Custom Assay Design Tools, Applied Biosystems Custom qPCR Primers and TaqMan Probes Tool, Chemical Storage and Management Resource Center, Solubility in water: 70g/L in water (20C). Consistent with a condensation reaction, water was determined to be the primary byproduct. Phase A: Dissolve L-Ascorbic Acid in distilled water via agitation and gentle heating (warm, never hot or you will denature the ascorbic acid). 57, 295300 (2013), R. F. Pires, M. R. Franco Jr, Fluid Phase Equilib. M1 and M2 microemulsions contain ethanol as co-surfactant. 43, 13111316 (2007), J. Qing-Zhu, M. Pei-Sheng, Z. Huan, X. Shu-Qian, W. Qiang, Q. Yan, Fluid Phase Equilib. [21][25][23] NTP evaluation showed some evidence of long-term carcinogenic and genotoxic effects[26], While hydroquinone remains widely prescribed for treatment of hyperpigmentation, questions raised about its safety profile by regulatory agencies in the EU, Japan, and USA encourage the search for other agents with comparable efficacy. 0000008435 00000 n 0000053439 00000 n Google Scholar, A.-C. Huang, Y.-K. Chuang, C.-F. Huang, C.-M. Shu, J. Therm. uv curable cellulose estersuv curable cellulose esters . . Some may double boil the hydroquinone and ester, I was too scared of the possibility of combustion. ChemPoint will not under any circumstances release personal user information to individuals or companies. One of these, 4-butylresorcinol, has been proven to be more effective at treating melanin-related skin disorders by a wide margin, as well as safe enough to be made available over the counter. Chem. Hydrogen peroxide is used and the reaction gives a mixture of hydroquinone and catechol: An accessible route involves the reaction of sodium hydroxide with 1,4-dichlorobenzene. This website uses cookies. These phases (described below) are combined in a mixing tank with an in-line homogenizer as follows. 20, 14331442 (1986), G. Wienke, J. Gmehling, Toxicol. Solubility of Hydroquinone. Solute (1 g) Water Boiling Water Alcohol Chloroform Ether Other Acenocoumarol 67,000 280 130 1800 Acetaminophen 20 10 1 N sodium hydroxide, 15 Acetohexamide 230 210 Acetylcysteine 5 4 Acetyldigitoxin 6100 62.5 12 >10,000 Ammonium Alum 7 0.5 Aluminum Chloride 0.9 4 Aluminum Sulfate 1 Amantadine Hydrochloride 2.5 5.1 18 polyethylene glycol 400, 70 2005 Wiley-VCH, Weinheim. [Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O, trimethyl-[phenyl-bis(trimethylsilyloxy)silyl]oxysilane, C[Si](C)(C)O[Si](O[Si](C)(C)C)(O[Si](C)(C)C)C1=CC=CC=C1, C\C(=C/C=O)\C=C\C=C(\C=C\C1=C(CCCC1(C)C)C)/C, 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine, CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC, 2-[2-[2-[2-[2-[2-(2-dodecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol, C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1, O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C, [Na+].[Na+].[Na+]. 0000004433 00000 n The Density of hydroquinone is . At 40C, 4% hydroquinone compositions are more likely to excessively discolor and magnesium ascorbyl phosphate helps to stabilize the color, by preventing the brownish black discoloration and maintaining an amber color. Cationic salts of acidic ascorbyl esters, including inorganic salts, preferably magnesium ascorbyl phosphate, and amino acyl derivatives, preferably aminopropyl ascorbyl phosphate, are preferred in this invention. Hydroquinone is extensively used as a photographic developer, an antioxidant, and a stabilizing agent for readily oxidizable polymers. Hydroquinone is a white crystalline solid, poorly soluble in water, but more soluble in organic solvents. Most preferably, when both a water-soluble antioxidant, preferably sulfite, including but not limited to sulfites, bisulfites, metabisulfites, their salts and their derivatives, most preferably sodium metabisulfite, and a cationic salt of acidic ascorbyl esters, most preferably magnesium ascorbyl phosphate, are present, the color of the hydroquinone composition is stabilized in the neutral pH range, preferably for greater than about six months, more preferably for greater than about twelve months and most preferably for greater than about eighteen months. 0000005757 00000 n Water Solubility 73000 mg/L at 25C 2.6B pH pKa 4.0 - 4.7 pK1 = 9.9 2.12 Oxidation:Reduction Potential +286 mV at 25C and pH 7 ENVIRONMENTAL FATE/BIODEGRADATION These can be burning, redness, sensitization and irritation in some patients. Pigmentation disorders can take a variety of forms like hyperpigmentation and hypopigmentation, such as melasma (dark patches experienced in pregnancy), liver spots (which often develop with age), as a side effect of birth control pills, and as a persistent result of acne, bums, bites and other skin injuries, and vitiligo. Preparation, optimization and in vivo. Data 53, 199200 (2008), N. Sunsandee, S. Suren, N. Leepipatpiboon, M. Hronec, U. Pancharoen, Fluid Phase Equilib. Natural antioxidants could replace hydroquinone derivatives used in industry. 0000003660 00000 n Mobility in soil No additional information available 12.5. This range of pH has been preferred for hydroquinone compositions, because it has been believed that the hydroquinone is less likely to excessively discolor under acid conditions. 108. Hydroquinone Revision Date 24-Dec-2021 General Advice If symptoms persist, call a physician. So, does anybody know of another solvent I could use that has a higher solubility and is relatively non-toxic. Reddit and its partners use cookies and similar technologies to provide you with a better experience. Anal. However, the oil-soluble TBHQ is more hydrophobic with a distinctly increased log P value compared to HQ. [27] Several such agents are already available or under research,[28] including azelaic acid,[29] kojic acid, retinoids, cysteamine,[30] topical steroids, glycolic acid, and other substances. 2017-02-16T10:10:56+01:00 All information collection is solely used to support ChemPoint customers service communications. Table II shows that at 5C, 4% hydroquinone compositions maintain their white or light straw color with the addition of at least about 0.5% magnesium ascorbyl phosphate at the low pH ranges (from about 3.50 to about 5.50) and when about 1.0 to about 2.0% magnesium ascorbyl phosphate is used in the pH range of about 7.0. Hydroquinone, 99.5%, Thermo Scientific Chemicals 5g, Glass Bottle Quantity: 5g 50g 250g 1kg 5kg Packaging: Glass Bottle Plastic Drum Plastic bottle Description This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. A3, Free format text: However, these hydroquinone-containing compositions were in the acidic pH range and did not contain cationic salts of acidic ascorbyl esters, such as magnesium ascorbyl phosphate. Hydroquinone is used as a topical application in skin whitening to reduce the color of skin. By rejecting non-essential cookies, Reddit may still use certain cookies to ensure the proper functionality of our platform. 0000008514 00000 n Place water in container then bring the temperature to 15c in a boil bath then add products at this point when youre making the lotion u will need to add the other ingredients. Chemically, hydroquinone is designated as p-dihydroxybenzene; the empirical formula is C 6 H 6 O 2; molecular weight is 110.0. While the hydroquinone is effective for the pigmentation disorder treatment, retinoid is used for its skin treatment benefits. It is a reducmg agent that is reversibly oxidized to semiquinone and quinone. The disodium diphenolate salt of hydroquinone is used as an alternating comonomer unit in the production of the polymer PEEK. Van Haelst, P. Heesen, F. Van Der Wielen, H. Govers, Chemosphere 29, 16511660 (1994), Article The correlation coefficient is greater than 0.9937 for one of these two equations for the binary studied systems where the solvent is either water or 1-octanol. endstream endobj 276 0 obj <>stream Please sign in to view account pricing and product availability. Correspondence to Glycerol derivatives solubilise natural, hydrophilic antioxidants in biofuels. It is found in wheat, rye, and barley.It is a precursor to diverse industrial products including polymers and plasticizers, as well as being a component of a number of hair and skin conditioners. In another embodiment of the invention, hydroquinone and a protected retinoid are both combined in the composition. By clicking Accept, you consent to the use of cookies. Can be destroyed by oxidizing it with an oxidizing mixture. I did that by using 1 cup of cream, 4tbsp of hydroquinone and 4tbsp of water or solvent. 20grams ofhydroquinonein 20oz is liquid is 10%. https://doi.org/10.1007/s10765-020-02750-4. Data 53, 12781282 (2008), A. I would like to add retinol and kojic acid to it as well. It would be desirable to combine the pigmentation disorder treatment with this skin benefit ingredient in one composition. Hydroquinone is highly susceptible to ring substitution by Friedel-Crafts reactions such as alkylation. HYPERPIGMENTARY STAIN ELIMINATING CREAM FOR FACE SKIN AND ITS USE. 230, 176183 (2005), A. Apelblat, E. Manzurola, N. A. Balal, J. Chem. The solubility was increased by addition of ethanol, reached a maximum . Have an order or account question? One skilled in the art is familiar with the known protective system technologies, such as encapsulation and entrapment methodologies. Chim. You can expect to hear back from a ChemPoint product specialist within 1 business hour. Hydroquinone is soluble in alcohol solvents such as ethanol and methanol [17]. The color stability of the hydroquinone composition is promoted by one or more antioxidants in the hydroquinone phase, preferably sulfite, including but not limited to sulfites, bisulfites, metabisulfites, their salts and their derivatives, most preferably sodium metabisulfite, and a cationic salt of acidic ascorbyl esters, most preferably magnesium ascorbyl phosphate. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. By accepting all cookies, you agree to our use of cookies to deliver and maintain our services and site, improve the quality of Reddit, personalize Reddit content and advertising, and measure the effectiveness of advertising. This is seen at about a pH of 3.50 with at least about 2.0% magnesium ascorbyl phosphate, and again at a pH of about 6.5 to about 7.0 with at least about 2.0% magnesium ascorbyl phosphate. One embodiment of the invention is a composition which comprises hydroquinone (about 1% to about 12%, preferably about 2% to about 10%, more preferably about 2% to about 8%, more preferably with about 2% to about 4%, and most preferably about 3% to about 4%) and has a neutral pH of from about 5.5 to about 8.0, more preferably a pH of from about 5.5 to about 7.5, and most preferably at a pH of from about 6.0 to about 7.5. [17], An important reaction is the conversion of hydroquinone to the mono- and diamine derivatives. Toughness of the polymer increases due to the presence of flexible units in the backbone such as long chain diols (e.g., diethylene glycol, dipropylene glycol, triethylene glycol) or long chain saturated acids (e.g., adipic . Thermodyn. Inhalation Remove to fresh air. [21] The FDA officially banned hydroquinone in 2020 as part of a larger reform of the over-the-counter drug review process. Free format text: The present invention addresses the problem of excessive discoloration in hydroquinone compositions of a neutral pH. Hydroquinone (C6H4(OH)2), also known as benzene-1,4-diol or quinol, is an aromatic organic compound, with a variety of uses in chemistry. The Campaign for Safe Cosmetics has also highlighted concerns. Recent pieces of . 38, 40814091 (1999), J. Qingzhu, M. Peisheng, Y. Shouzhi, W. Qiang, W. Chang, L. Guiju, J. Chem. How do I dissolve hydroquinone powder to make a 20% and 10% concentration? Other aspects, advantages, and modifications are evident from a review of the following claims. 552591, Z. Esina, M. Korchuganova, Theor. Conversion factors (at 25C and normal atmospheric pressure) 1 ppm = 4.5 mg/m 3 1 mg/m 3 = 0.222 ppm Table 1. In 1-octanol, the decreasing order of the solubility of these compounds is as follows: resorcinol>benzoic acid>salicylic acid>hydroquinone. 0.6. glycerin, 2.5. uuid:3780f5dc-b322-4e29-9b1d-4c4d10b1e282 English, J.C. and Deisinger, P.J. The solubility of sodium phenytoin in binary mixtures of ethanol +water at 298.2, 303.2, 308.2 and 313.2 K was measured. We have discovered that a hydroquinone composition (with about 1 to about 12% hydroquinone, preferably with about 2% to about 10%, more preferably with about 2% to about 8%, more preferably with about 2% to about 4%, most preferably with about 3% to about 4% hydroquinone) with preferably a pH of from about 5.5 to about 8.0, more preferably a pH of from about 5.5 to about 7.5, and most preferably at a pH of from about 6.0 to about 7.5, can include cationic salts of acidic ascorbyl esters, preferably sodium ascorbyl phosphate, more preferably aminopropyl ascorbyl phosphate, most preferably magnesium ascorbyl phosphate as an antioxidant and the color destabilization problems are appreciably less as compared to hydroquinone compositions without such a cationic salt of acidic ascorbyl esters in the neutral pH range: preferably a pH of from about 5.5 to about 8.0, more preferably a pH of from about 5.5 to about 7.5, and most preferably at a pH of from about 6.0 to about 7.5. 250, 165172 (2006), F. L. Mota, A. J. Queimada, A. E. Andreatta, S. P. Pinho, E. A. Macedo, Fluid Phase Equilib. Calorim. Hydroquinone occurs in the environment as a result of anthropogenic processes, as well as in natural products from plants and animals. For a shipping quote, check the box and the bottom and provide us your shipping information. 15, 188196 (1996), U. Domaska, Fluid Phase Equilib. [31], Hydroquinones are one of the two primary reagents in the defensive glands of bombardier beetles, along with hydrogen peroxide (and perhaps other compounds, depending on the species), which collect in a reservoir. . 0000000807 00000 n 58 / Monday, March 26, 2012 / Rules and Regulations 10/31/2017 EN (English US) 6/8 12.3. :hS-g"s2Sj Ij=x'V]gPV8tt~qkAVXi|u}5;#.pl-/4JFQ.EP3&F.qa2hI{N qBmG(z#n [GN.}aazN(~8kux9#tnYwIHFuxW v9UNj&ffNW_\\Tc""8=_"7wC>svwQy\^4gF H][QzmlOI(B@ U4[Xb0,|m0*D"/#$\u(QI)RYg\;8 Yjh Exceptional antioxidant qualities are seen at 0.10% (all percentages in the application are weight percent) and above, preferably from about 0.05% to about 0.5% for sodium metabisulfite. ;O,1Y+%8#oKT^VWtew4>@V.SR :hmBZ>#ey!UC5! / /n Also in this embodiment is a cationic salt of acidic ascorbyl esters, which further helps to maintain the acceptable color desired in the hydroquinone composition. isosorbide, Ascorbic acid, i.e. V)gB0iW8#8w8_QQj@&A)/g>'K t;\ $FZUn(4T%)0C&Zi8bxEB;PAom?W= I understand the concentrations are high but I have used them before, its just too expensive to keep buying from a compounding pharmacy. Eng. NR 1L~tyj|ZZ3]jFlszH#bd]="nVj =rBF-=Y?Pe 3(\[3;wR-+7Fn ~pSQ(Rpiw^zYr''t@\vobE]u'C}io0q;^k5C@|zZNNA>,XOrztV;qO*w:MC$OI\_$Io 'v [ Remove contact lenses, if present and easy to do. As a polymerisation inhibitor, exploiting its antioxidant properties, hydroquinone prevents polymerization of acrylic acid, methyl methacrylate, cyanoacrylate, and other monomers that are susceptible to radical-initiated polymerization. Hydroquinone[1] Idrochinone Quinol 1,4-Dihydroxybenzene p-dihydroxybenzene p-hydroxyphenol 1,4-Hydroxy benzene Identifiers CAS Number 123-31-9 Y 3D model (JSmol) Interactive image Beilstein Reference 605970 ChEBI CHEBI:17594 Y ChEMBL ChEMBL537 Y ChemSpider 764 Y DrugBank DB09526 ECHA InfoCard 100.004.199 EC Number 204-617-8 Gmelin Reference 2742 Phillip M. Hudnall "Hydroquinone" in Ullmann's Encyclopedia of Industrial Chemistry 2002, Wiley-VCH, Weinheim. Cookie Notice Hydroquinone can be made through several routes. Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. Retinoid compositions, in particular retinoic acid, retinal, and their derivatives, isomers and analogs (such as adapalene, tazarotene and isotretoin) are known to be effective in improving rough skin texture, mottled pigmentation, sallow complexion, lines and wrinkles. Skin Contact Wash off immediately with plenty of water for at least 15 minutes. Retinoids are included in the invention from about 0.01 to about 5%, preferably from about 0.025% to about 2.0%, more preferably from about 0.05% to about 1%, and most preferably from about 0.025% to about 0.5%. The aquatic toxicity of hydroquinone to fresh water fish, Daphnia, and algae was between 0.050- . Although about 0.01% sodium metabisulfite without magnesium ascorbyl phosphate may not color stabilize an about 4% hydroquinone composition, and about 0.5% magnesium ascorbyl phosphate without sodium metabisulfite may not either, the combination of sodium metabisulfite and magnesium ascorbyl phosphate in these percentages is effective to stabilize the color of the about 1% to about 12%, about 2% to about 10%, preferably about 2% to about 8% and more preferably about 3% to about 4% and most preferably 4% hydroquinone composition. 29(3): 283-330, 1999. 330, 4851 (2012), A. Shalmashi, A. Eliassi, J. Chem. Phase A is added to the tank, which is held at a temperature of from about 70 to about 75 C, and in which a CO. C6H4O2) is formed. Availability. It has a white-solid appearance. At 40C, 4% hydroquinone compositions have the same color stability with slightly more sodium metabisulfite, at least about 0.01% at about 3.5 to about 4.0 pH; at least about 0.05% sodium metabisulfite at about 4.5 to about 6.0 pH; and at pH; at least about 0.05% sodium metabisulfite at about 4.5 to about 6.0 pH; and at least about 0.10% sodium metabisulfite at about 6.5 to about 7.0 pH. Therefore, the solubility values of hydroquinone in different solvents are required; however, the data availability in the literature is poor.3-7 In this work, the solubility data of hydroquinone in water, methanol, ethanol, 2-propanol, ethyl acetate, butyl acetate, and acetic acid from 276.65 K to 345.10 K under atmospheric pressure were . antiphlogistics and cardiaca, Cosmetics or similar toilet preparations characterised by the composition, Cosmetics or similar toilet preparations characterised by the composition containing inorganic ingredients, Sulfur; Selenium; Tellurium; Compounds thereof, Cosmetics or similar toilet preparations characterised by the composition containing organic compounds, Cosmetics or similar toilet preparations characterised by the composition containing organic compounds containing oxygen, . Hydroquinone compositions are effective but have some undesirable side effects. I can only tell you how to mix the powder solution to the liquid solvent. 374 0 obj << /Linearized 1 /O 376 /H [ 807 1414 ] /L 581425 /E 96582 /N 109 /T 573826 >> endobj xref 374 19 0000000016 00000 n 388, 7381 (2010), H. Li, G. Hu, F. Guo, L. Zhao, J. Zhu, Y. Zhang, Can. Data 51, 16681671 (2006), C. L. Yaws, S.-C. Lin, Enthalpy of fusion at freezing pointOrganic compounds, in Thermophysical Properties of Chemicals and Hydrocarbons, William Andrew Publishing (Elsevier, 2009), pp. Eng. It can also be found on eBay and Amazon. 77, No. There are various other uses associated with its reducing power. uuid:a150f3fd-7f22-4439-aa26-6f445f4017e5 It is a major component in most black and white photographic developers for film and paper where, with the compound metol, it reduces silver halides to elemental silver. We apologize! application/pdf 109. Using a laser-monitoring observation technique, the solubility of hydroquinone in water, methanol, ethanol, 2-propanol, ethyl acetate, butyl acetate, and acetic acid were measured at temperatures ranging from 276.65 K to 345.10 K under the atmospheric pressure. InChI=1S/C6H6O2/c7-5-1-2-6(8)4-3-5/h1-4,7-8H, InChI=1/C6H6O2/c7-5-1-2-6(8)4-3-5/h1-4,7-8H, Except where otherwise noted, data are given for materials in their. fungichromin, Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. For use herein, the encapsulation forms a protective system to prohibit or inhibit the oxidation of the retinoid. The most preferred example of such an antioxidant is sodium metabisulfite. GHS H Statement: Causes serious eye damage.Suspected of causing genetic defects.May cause an allergic skin reaction.Suspected of causing cancer.Harmful if swallowed.Very toxic to aquatic life. vz >I d50dwp?i4,H3. Polysorbate 20 0.5% 0.15g. Other adverse effects 0000002544 00000 n They may also include ingredients with other therapeutic actions, such as anti-inflammatories, antibiotics, exfoliants and peels. . D-170D Solubility of EASTMAN Hydroquinone and Derivatives Subject: Hydroquinone and hydroquinone derivatives listed in this publication are used as intermediates for manufacturing a variety of products and as polymerization inhibitors for vinyl monomers and unsaturated polyester resins. [Na+].OC[C@H](O)[C@H]1OC([O-])=C(OP([O-])([O-])=O)C1=O, N1=CC(C(=O)OCC)=CC=C1C#CC1=CC=C(SCCC2(C)C)C2=C1, C1=C(C(O)=O)C=CC2=CC(C3=CC=C(C(=C3)C34CC5CC(CC(C5)C3)C4)OC)=CC=C21, CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C, disodium;2-[2-[carboxylatomethyl(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetate, [Na+]. [34], It is also one of the chemical compounds found in castoreum. The method of item 1 07 wherein the hydroquinone is present in about 4%. SAS Anti-ox booster 1% 0.3g. Fill out the form below, and we will send you the document as soon as we can! Variations in pH have proven to result in excessive discoloration ranging from brownish to black. Get medical attention. &"oq YcbX.=a*t R@ 0000002585 00000 n With an account you can check out faster, view your online order history and access your shopping bag or saved items from any device. Hydroquinone IS a white crystalline substance when pure and is highly soluble in water. Hydroquinone is a white crystalline solid, poorly soluble in water, but more soluble in organic solvents. Toxicol. 49, 313321 (2015). [19][20], In 2006, the United States Food and Drug Administration revoked its previous approval of hydroquinone and proposed a ban on all over-the-counter preparations.
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