ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. Erythrocytosis and Polycythemia Secondary to Testosterone Replacement Therapy in the Aging Male. KEY POINTS Testosterone therapy can cause secondary erythrocytosis. To offer clinical suggestions for therapy in patients at risk for veno‐thrombotic events. In secondary polycythemia, your EPO level will be high and you’ll have a high red blood cell count. ISSN 1470-3947 (print) | ISSN 1479-6848 (online) Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences. To the extent that the increased RBCs alleviate tissue hypoxia, secondary polycythemia may in fact be beneficial. Secondary erythrocytosis, which is more common than PV, has a broad differential diagnosis that includes hypoxic lung disease, cyanotic congenital heart disease, medications (e.g., testosterone) and erythropoietin-producing malignant disorders. Clinically, this response is described as erythrocytosis or polycythemia secondary to TRT. Polycythaemia was defined as at least one haemoglobin concentration ≥17 g/dl or packed cell volume ≥0.505. To discuss potential etiologies for this response, the role it plays in risk for VTE, and recommendations for considering treatment in at‐risk populations. treatment group (19.4%) than the transdermal group (13.1%), as was peak haemoglobin concentration (15.58 vs 15.00 g/dl) though only the later was statistically significant (P<0.05). To assess the mechanisms of TRT‐induced erythrocytosis and polycythemia with regard to basic science, pharmacologic preparation, and route of delivery. A literature review was performed through PubMed regarding TRT and erythrocytosis and polycythemia. 155 (72%) were treated with i.m. Contrary to other studies, no association was found between development of polycythaemia and older age. The evidence regarding the risk for VTE with increased Hct is inconclusive. Absolute polycythemia occurs when more RBCs are produced than normal and their count is truly elevated. Medical Care Correction of the underlying cause of secondary polycythemia is the most important element of managment. A raised PSA was defined as >4.4 μg/l. However, the recent Food and Drug Administration warning regarding the risk for venothromboembolism (VTE) has made the increases in Hb and Hct of more pertinent concern. Different testosterone formulations are available, with significantly different half-lives, which have varying influences on the development of secondary polycythemia. Privacy policy | We use cookies to help provide and enhance our service and tailor content and ads. Recent meta‐analyses have revealed that increases in hemoglobin (Hb) and hematocrit (Hct) are the variants most commonly encountered. Jones SD Jr, Dukovac T, Sangkum P, Yafi FA, and Hellstrom WJG. One is polycythemia (also called erythrocytosis). Men with low to low‐normal levels of testosterone have documented benefit from hormone replacement. Clinically, this response is described as erythrocytosis or polycythemia secondary to TRT. The risks associated with androgen replacement need further examination. Burning sensations of the hands or feet Copyright © 2015 International Society for Sexual Medicine. Clinically, this response is described as erythrocytosis or polycythemia secondary to TRT. Erythropoietin-secreting tumors (eg, hepatocellular carcinoma, renal cell carcinoma, adrenal a… Recent meta-analyses have revealed that increases in hemoglobin (Hb) and hematocrit (Hct) are the variants most commonly encountered. Copyright © 2021 Elsevier B.V. or its licensors or contributors. To review Hct and risk for thrombotic events. Background: Testosterone replacement is the mainstay of treatment for male hypogonadism. Guys and St Thomas Hospital, London, UK. Background:Polycythemia is the most common adverse effect of testosterone replacement therapy (TRT) and may predispose patients to adverse vascular events.Current Canadian guidelines recommend regular laboratory monitoring and discontinuing TRT or reducing the dose if the hematocrit exceeds 54% (hemoglobin ≥180 g/L). Recent meta‐analyses have revealed that increases in hemoglobin (Hb) and hematocrit (Hct) are the variants most commonly encountered. This topic discusses the causes of polycythemia and our approach to evaluation and diagnosis. This may include cessation … Data suggest that testosterone therapy has effects that may counteract the potentially increased risk of venous thromboembolism. Some take testosterone to manage symptoms like low libido, moodiness, and fatigue. Testosterone replacement therapy (TRT) is a common treatment for hypogonadism in aging males. Lightheadedness 5. The increase in hemoglobin and hematocrit secondary to testosterone use is usually accompanied by an increase in the red blood cell count, which can lead to an increase in blood viscosity. Recent meta‐analyses have revealed that increases in hemoglobin (Hb) and hematocrit (Hct) are the variants most commonly encountered. Clinically, this response is described as erythrocytosis or polycythemia secondary to TRT. Men undergoing TRT have a 315% greater risk for developing erythrocytosis (defined as Hct > 0.52) when compared with control. 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